(Generate Random Synthesis)
#278 Alcohol Elimination
#290 Epoxide Opening (acid)
#031 Stereospecific E2, Bromination
#025 E2, Bromohydrin Epoxidation
#543 Alkene-Alkyne
#044 Acetylide Epoxide Opening
#058 Acetylide Sn2, BH3-Ox, Tautomerize
#020 Acetylide Sn2, Lindlar's Catalyst
#024 Hydrobromination, E2, Ozonolysis
#046 Radical Br, E2, Ozonolysis Ring Open
#277 Sn2 Direction (leaving group sterics), Radical Setup
#005 Alkene Radical Setup Sn2
#034 Diels-Alder Alkyne Double Addition
#035 Diels-Alder Stereospecificity
#059 EAS Substituent Order
#060 Benzylic Functionalization, EAS Order
#037 F-C Alkylation, Benzylic Oxidation
#125 PABA: EAS, Benzylic Oxidation
#293 Intramolecular Friedel-Crafts, Cyclic Anhydride
#040 Radical Setup, Organometal > Aldehyde
#021 Organometallic Double Addition to Ester
#041 Organometal Epoxide Opening, Oxidation
#289 Epoxide Opening (organometal), Radical Setup
#022 Organocuprate Conjugate Addition
#028 Wittig, Alcohol Oxidation
#029 Enamine Formation (cyclic amine + cyclic ketone)
#030 Intramolecular Enamine Hydrolysis
#027 Protecting Group (Acetal), Ester Reduction
#055 Organometallic Addition to Aldehyde, Acetal Protecting Group
#126 Aspirin: EAS, Benzylic Oxidation, Acylation
#545 Aniline - Amide Protecting Group
#056 Nitrile Reduction, Acid > Acyl Chloride, Amide Formation
#124 Ibuprofen: EAS, Redox, Sn2, Nitrile Hydrolysis
#294 Nitrile-Carboxylic Acid
#057 Alpha-Halogenation, Sn2, Active Enolate Alkylation
#061 Direct Enolate Alkylation
#062 Malonic Ester Synthesis
#063 Acetoacetic Ester Synthesis, Di-halide Cyclization
#067 Ring expansion, organometal ketone add, dehydration, ozonolysis, aldol condensation
#096 Diels-Alder, Aldol Condensation
#066 Crossed Claisen, Aldol Condensation
#064 Intramol Aldol Condensation, Michael Addition
#097 Diels-Alder, Robinson Annulation
#090 Gabriel Synthesis (primary allylic amine)
#091 Amide Formation, Reduction to Amine
#089 Sandmeyer (CuCN), Reduction to Amine
#094 Acetaminophen: Arenediazonium, EAS, Acetylation
#095 Benzene - Tri-meta-bromination
#121 Diazo Coupling, F-C Alkylation
#047 Stille Coupling, Phenol Triflate Prep
#049 Stille Carbonylate Coupling, EAS Nitration
#048 Intramolecular Heck (quaternary center), EAS Prep
#050 Heck Reaction (successive), EAS Nitration
#051 Heck (cyclic alkene), Epoxidation
#087 Kinetic Enolate Triflate Prep, Heck Reaction
#119 Wohl Degradation, Oxidation -> Lactone
#120 Kiliani-Fischer Synthesis, Oxidation -> Aldaric Acid
#117 Aminomalonate Alkylation: Phenylalanine
#118 Strecker Amino Acid: Valine
#116 Dipeptide Synthesis
#038 SnAr, Epoxide Opening (organometal)
#092 Heteroaromatic EAS, Stille Coupling
#093 Naphthlaene EAS, Arenediazonium F
#122 Aromatic Claisen RAR, Allylic Sn2 Setup
#123 Acetylide, Ketone Addition, Electrocyclization
#292 Carboxylic Acid-Nitrile
#546 EAS Blocking Group
#547 SnAr, Phenol Prep
Sample
Sample 5.00 - Alkenes
Sample 10.00 - Alcohols and Epoxides
Sample 16.00 - Electrophilic Aromatic Substitution
Sample 18.00 - Transition Metal (Pd) Catalysis
Sample 19.00 - Aldehydes and Ketones
Sample 21.00 - Carboxylic Acid Derivatives
Sample 22.04 - Aldol Chemistry and Michael Addition
Sample 22.08 - Organometallic Addition, Conjugate Addition
Sample 23.10 - Arenediazonium Reactions
Sample 25.00 - Pericyclic Reactions
Sample 26.04 - Amino Acid Synthesis
Generate Problem
Reaction Drills produce a series of (ungraded) reaction equations with one hidden
component (reactant, reagent or product) and asks you to mentally
"fill-in-the-blank" to test and train your skill, similar to flashcards.
The primary interface for solving multi-step synthesis design problems and
for freely exploring different reactant and reagent combinations.
Reactions support curved-arrow mechanism diagram viewing and exploration
to not only show "what" a reaction will produce,
but to also explain "how" the reaction will proceed.
Introduction Video